Perineural Injection Therapy: Calming Inflamed Nerves at the Source

For those whose nerve pain hasn't responded to conventional care

For individuals with chronic pain unresponsive to conventional approaches, Perineural Injection Therapy (PIT) represents an emerging option. Developed by Dr. John Lyftogt, it operates differently from traditional pain management.

Unlike pain medications that mask symptoms or surgeries that carry significant risks, PIT addresses the root cause of many chronic pain conditions by helping the nerves themselves heal.

What Is Perineural Injection Therapy?

PIT involves administering small quantities of dextrose solution around inflamed nerves to decrease swelling, facilitate healing, and restore proper nerve function. Dr. Lyftogt, a New Zealand physician, created this approach based on extensive research into nerve inflammation and pain mechanisms.

How It Works

Nerve inflammation develops from injury, repetitive stress, compression, or other causes — a condition called perineural inflammation. Injected around the nerve, dextrose works through several mechanisms:

Osmotic effect — Establishes a gradient that pulls excess fluid away from inflamed nerve tissue, reducing swelling and pressure.

Controlled anti-inflammatory response — Activates the body's inherent healing mechanisms rather than suppressing them.

Nerve regeneration — Encourages new nerve fiber growth and supports restoration of proper function.

Pain signal interruption — By reducing nerve inflammation, the therapy interrupts pain signals transmitted to the brain.

Conditions We See Respond to PIT

• Neuropathic pain
• Nerve compression syndromes
• Headaches and migraines
• Joint pain with a clear nerve component
• Fibromyalgia
• Post-surgical pain
• Sports injuries

What a Session Looks Like

Sessions typically take 15–30 minutes. After a thorough evaluation to identify which nerves are driving the pain, small quantities of dextrose solution are injected around the affected nerve. Most patients report minimal discomfort.

A standard course is 3–6 sessions spaced 1–2 weeks apart. Some patients feel relief after the first injection; comprehensive benefits build over weeks as the nerve heals.

Where the Evidence Points

Dr. Lyftogt's clinical research suggests that for patients who failed conventional treatments, PIT can:

• Reduce pain meaningfully
• Improve function and quality of life
• Produce results lasting months to years
• Reduce the need for pain medication
• Avoid the risks of surgery

Why We Combine PIT with TCM, Functional Medicine, and Physiotherapy

PIT is significantly more effective as part of an integrated approach.

PIT + Functional Medicine addresses the systemic factors — inflammation, blood sugar, nutrient deficiencies — that created the nerve inflammation in the first place.

PIT + TCM promotes Qi flow and blood circulation to the affected areas so the nerve has what it needs to rebuild.

PIT + Physiotherapy restores the movement patterns and strength that prevent the inflammation from returning.

Safety Profile

PIT is well-tolerated:

• Temporary soreness at injection sites (24–48 hours)
• Sometimes a brief increase in pain as healing activates
• Occasional mild bruising

Serious complications are extremely rare when administered by a trained practitioner.

Is PIT Right for You?

If you're dealing with chronic, nerve-related pain that hasn't responded to medication, physical therapy, or surgery, PIT is worth a conversation. Take the free assessment or book the program to discuss your specific situation.